• Mother Ann Rhodes June 29, 1812 – December 11, 1812
• Mother Mary Rhodes December 1812-1822
• Mother Juliana Wathen February 8, 1822 – 1824
• Mother Isabella Clarke 1824 – 1826
• Mother Sabina O’Brien 1826 – 1832
• Mother Josephine Kelly 1832 – 1838
• Mother Isabella Clarke 1838 – 1842
• Mother Generose Mattingly 1842 -1844
• Mother Berlindes Downs 1844 – 1846, 1846 – 1852
• Mother Bridget Spalding 1852 – 1855, 1855 – 1858
• Mother Berlindes Downs 1858 – 1861, 1861 – 1864
• Mother Bertha Bowles 1864 – 1867, 1867 – 1870
• Mother Elizabeth Hayden 1870 – 1873, 1873 – 1876
• Mother DaFrosa Smythe 1876 – 1879, 1879 – 1882
• Mother Ann Joseph Mattingly 1882 – 1885, 1885 – 1888
• Mother DaFrosa Smythe 1888 – 1889, 1891 – 1893
• Mother Catherine Connor 1893 – 1894, 1894 – 1896
• Mother Praxedes Carty 1896 – 1898, 1901 – 1922
• Mother Clarasine Walsh 1922 – 1928
• Mother Olivette Norton 1928 – 1934, 1934 – 1940
• Mother Edwarda Ashe 1940 – 1946, 1946 – 1952
• Mother Felicitas Quinlivan 1952 – 1958
• Mother Mary Luke Tobin 1958 – 1964, 1964 – 1970

As of 1970, Loretto Major Superior referred to as “President”

• Sister Helen Sanders 1970-1974, 1974-1978
• Sister Marian McAvoy 1978-1982, 1982-1986
• Sister Maureen McCormack 1986-1990, 1990-1994
• Sister Mary Ann Coyle 1994-2000
• Sister Mary Catherine Rabbitt 2001-2006
• Sister Catherine Mueller 2007-2012
• Sister Pearl McGivney 2013-2018
• Sister Barbara Nicholas 2019-present